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PEG hydrogenated castor oil – Solubilizer & bioavalability enhancer

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    1/ Introduction

    PEG (polyoxyl) hydrogenated castor oils are a group of excipients that function as solubilizers, emulsifiers, permeability enhancers, and bioavailability enhancers, and are widely used in pharmaceutical manufacturing. These excipients are applied in various liquid and semi-solid dosage forms such as injections, oral suspensions, herbal syrups, and topical creams/gels/ointments. Polyoxyl hydrogenated castor oil and its derivatives include:

    • Polyoxyl 40 hydrogenated castor oil
    • Polyoxyl 40 hydrogenated castor oil + propylene glycol
    • Polyoxyl 35 hydrogenated castor oil

    2/ Key Advantages

    • Freely soluble in water, alcohol, and ethyl acetate
    • Stable without developing off-odors under recommended storage conditions
    • Mechanism of solubilization and permeability enhancement: modifies water polarity; adjusts properties such as density, surface tension, viscosity, melting point, and specific heat of the solution; reduces the contact angle between solute and solvent; increases solvate (hydrate) formation of the solute; reduces solute particle size to molecular levels
    • High HLB value (13–17), enhancing solubilization and permeability efficiency
    • Acid value, saponification value, and iodine value are controlled within pharmacopeial limits
    • Odorless and tasteless, with no impact on the sensory properties of the formulation
    • Product complies with USP/EP/BP
    • The manufacturer has EXCIPACT GMP Certificate for Pharma application
    • Stock available at GSP/ GDP warehouse, prompt delivery, competitive price

    3/ Applications

    • Oral use: acts as a solubilizer, emulsifier, permeability enhancer, and taste-masking agent for certain active ingredients
    • Topical use: functions as a solubilizer and permeability enhancer, with the ability to form a smooth, soft film
    • Recommended active ingredients: fat-soluble vitamins (vitamins A, D, E), poorly water-soluble herbal extracts, paracetamol, bromhexine HCl, ambroxol HCl, dextromethorphan HBr, cyproheptadine, etc.

    4/ Commercial Products

     

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    02-04 Alexandre De Rhodes Street, Sai Gon Ward, Ho Chi Minh City 70000, Vietnam0834560500bm@summ.vn
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    02-04 Alexandre De Rhodes Street, Sai Gon Ward, Ho Chi Minh City 70000, Vietnam0834560500bm@summ.vn
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